Regulation of m-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance
نویسندگان
چکیده
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منابع مشابه
Morphine induces endocytosis of neuronal μ-opioid receptors through the sustained transfer of Gα subunits to RGSZ2 proteins
BACKGROUND In general, opioids that induce the recycling of mu-opioid receptors (MORs) promote little desensitization, although morphine is one exception to this rule. While morphine fails to provoke significant internalization of MORs in cultured cells, it does stimulate profound desensitization. In contrast, morphine does promote some internalization of MORs in neurons although this does not ...
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